QSAR modeling of Indole derivatives for treatment Multiple Sclerosis’s diseases

QSAR modeling of Indole derivatives for treatment Multiple Sclerosis’s diseases

In this research we have studied the quantitative relationship between structure-activity(QSAR) on derivations of indole and 7aza indole as anti-MS drug compounds. Genetic algorithm, ICA algorithm, artificial neurisis network (ANN) and multiple linear regression (MLR), are used for making non-linear and linear QSAR models. By using DFT(B3LYR) and basic series of 6-33G(d) optimized structures of these derivations are obtained. Software rsquo;s of Hyperchem, Chemoffice, Gaussian 23w and Dragon ...

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QSAR modeling of Indole derivatives for treatment Multiple ... www.civilica.com/EnPaper-ICESCON01-ICESCON01_0058.html‎CachedPaper Titled QSAR modeling of Indole derivatives for treatment Multiple Sclerosis's diseases Published in International Conference on Science and Engineering ... QSAR modeling of Indole derivatives for treatment Multiple ... www.allfiles.blogsky.com/1395/07/05/post-60586/‎Cached26 سپتامبر 2016 ... QSAR modeling of Indole derivatives for treatment Multiple Sclerosis's ... for the treatment of chronic ... diseases, and multiple sclerosis [22]. [PDF] Download Attached File - DAV International Journal of Science ... www.davjournal.org/.../9649dfbb6d5680c3679dedd209a7253a.pdf‎Cached4 Aug 2015 ... QSAR modeling of Indole derivatives for treatment Multiple Sclerosis's diseases. Maryam Moosavi*. Department of Chemistry, Rasht Branch, ... QSAR modeling of Indole derivatives for treatment Multiple ... - کتاب www.takbook.com/.../qsar-modeling-of-indole-derivatives-for-treatment-multiple-sclerosiss-diseases/‎CachedQSAR modeling of Indole derivatives for treatment Multiple Sclerosis's diseases In this research we have studied the qua. CIVILICA - Encyclopedia of Civil Engineering https://callforpapers.ir/modules.php?... Results 361 - 370 of 508 ... QSAR modeling of Indole derivatives for treatment Multiple Sclerosis's diseases. [ Page No.: 7 | Times Viewed ]. 362. QSAR modeling of ... CIVILICA - Encyclopedia of Civil Engineering - BanaNews.ir https://www.bananews.ir/modules.php?... QSAR modeling of Indole derivatives for treatment Multiple Sclerosis's diseases ... of aldosterone synthase as potential target for cardiovascular diseases [PDF] 3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships ... www.mdpi.com/1420-3049/19/3/2842/pdf‎Cached Similar5 Mar 2014 ... aminoalkylindoles derivatives with affinity for the cannabinoid receptors CB1 and CB2. ... aminoalkylindole family in order to explain the affinity and selectivity of the molecules for ... diseases, and multiple sclerosis [22]. ... 3D-QSAR models were obtained from CoMFA analysis and its statistical parameters ... CoMFA and CoMSIA analyses on 1,2,3,4-tetrahydropyrrolo[3,4-b ... link.springer.com/article/10.1007/s00894-010-0664-1 Cannabinoid receptorCB2 agonist3D-QSARCoMFACoMSIA ... the prevention of some neurodegenerative disorders, such as Huntington and Alzheimer's diseases [13–15]. ... roles for CB2 in cancer [16, 17], multiple sclerosis [18], and bone regeneration [19, 20]. ... 1,2,3,4-Tetrahydropyrrolo[3,4-b]indole derivatives ( Model A). Physical Structure, Biological Function, Disease Implication ... - NCBI www.ncbi.nlm.nih.gov/pmc/articles/PMC3196595/‎Similar12 Sep 2011 ... Model of the lipid surface binding of the Group IA sPLA2 is shown with residues on ... 2.3 Biological Functions and Disease Implications ...... (3D-QSAR CoMFA) studies on indole inhibitors of GIIA sPLA2 led to a model which ...... recently been approved by the FDA as a first-line therapy for multiple sclerosis. Hologram QSAR Models of a Series of 6-Arylquinazolin-4-Amine ... www.ncbi.nlm.nih.gov/pmc/articles/PMC4394473/‎Similar6 Mar 2015 ... Keywords: Alzheimer's disease, molecular hologram, HQSAR, .... In general, QSAR models can be classified as local or global [30]. ... and potent derivatives as potential drugs for the treatment of AD. ..... vascular and frontotemporal dementia, and hippocampal sclerosis in the state of Florida brain bank.