Optimization of sustained release delivery Olanzapine system

Optimization of sustained release delivery Olanzapine system

The objective of this study is to develop controlled release formulation of water insoluble Olanzapine (OZ), using Glycerol monooleate (GMO) and Polyethylene glycol (PEG 300). A Box-Benkhen response surface methodology was applied to design gel system with 3 factors with an initial drug containing within the range of 2-4%, weight ratio of GMO/water (w/w) in the range of 2-4% and weight ratio of PEG 300/GMO (w/w) in the range of 2-6%. Dependent variables include entrapment efficacy (EE %), ...

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