In silico potential vaccine against oprF in multidrug-resistant Pseudomonas aeruginosa

In silico potential vaccine against oprF in multidrug-resistant Pseudomonas aeruginosa

Pseudomonas aeruginosa is an important cause of nosocomial infection and may lead to septicemia and death. P. aeruginosa septicaemia is associated with the highest mortality rate of all Gram-negative infections. Because of the general resistance of the organism to antibiotics, research has been focused on immunotherapy. There are several bacterial cell components incorporated into subunit vaccines. Vaccine studies have often focussed on lipopolysaccharide (LPS) and the outer membrane proteins ...

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In silico determination and validation of oprL structure and b cell epitopes as vaccine candidate in Pseudomonas aeruginosa

In silico determination and validation of oprL structure and b cell epitopes as vaccine candidate in Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic, non-fermentative, gram-negative rod which is an important cause of nosocomial infection leading to septicemia and death. The mortality rate is higher than bacteremias caused by other gram-negative opportunistic pathogens. One of the most important features of the bacterium is its resistance to various antibacterial agents, and even newly developed antibiotics have failed to reduce the mortality rate associated with this organism. There is increasing ...

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In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

Haemophilus parasuis is a small, pleomorphic, NAD-dependent member of the family Pasteurellaceae. This bacterium is the etiological agent of Gl auml;sser rsquo;s disease in swine, which is characterized by polyserositis and arthritis. Once a sporadic disease, it has increased in prevalence and severity in recent years with the adoption of new production technologies which has led to pigs being susceptible to this infection. However, a lack of protective cross-immunity against some strains and ...

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