QSAR study of 1- Aminobenzyl-1H-indazole-3-carboxamide Analogues For the treatment of Hepatitis C

QSAR study of 1- Aminobenzyl-1H-indazole-3-carboxamide Analogues For the treatment of Hepatitis C

In this work quantitative structure-activity relationship (QSAR) study has been done on 1- Aminobenzyl-1H-indazole-3-carboxamide Analogues as anti-Hepatitis C drugs. Genetic algorithm (GA), artificial neural network (ANN) were used to create QSAR models. The root-mean square errors of the training set and the test set for GA models using the jack-knife method, were 741.73, 741375and R0 = 7.68. The results obtained from this work indicate that ANN and GA models are more effective than other ...

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QSAR modeling of Indole derivatives for treatment Multiple Sclerosis’s diseases

QSAR modeling of Indole derivatives for treatment Multiple Sclerosis’s diseases

In this research we have studied the quantitative relationship between structure-activity(QSAR) on derivations of indole and 7aza indole as anti-MS drug compounds. Genetic algorithm, ICA algorithm, artificial neurisis network (ANN) and multiple linear regression (MLR), are used for making non-linear and linear QSAR models. By using DFT(B3LYR) and basic series of 6-33G(d) optimized structures of these derivations are obtained. Software rsquo;s of Hyperchem, Chemoffice, Gaussian 23w and Dragon ...

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Using Analytical Hierarchy Process (AHP) for Selecting the Best Wastewater Treatment Process (Case Study in Amol City)

Using Analytical Hierarchy Process (AHP) for Selecting the Best Wastewater Treatment Process (Case Study in Amol City)

In current work, Analytical Hierarchy Process (AHP) method is applied to select the ideal anaerobicwastewater treatment process. This strategy can be used for complex multi-criteria choice making toget perceptible outcomes. The distinctive anaerobic procedures utilized in Iranian industrial domainsincluded Up-flow Anaerobic Baffled Reactor (ABR), Up-flow Anaerobic Sludge Blanket (UASB),Up-flow Anaerobic Fixed Bed Reactor (UAFB), Anaerobic Lagoons (AL) and Contact process (CP).The procedures are ...

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