In silico potential vaccine against oprF in multidrug-resistant Pseudomonas aeruginosa

In silico potential vaccine against oprF in multidrug-resistant Pseudomonas aeruginosa

Pseudomonas aeruginosa is an important cause of nosocomial infection and may lead to septicemia and death. P. aeruginosa septicaemia is associated with the highest mortality rate of all Gram-negative infections. Because of the general resistance of the organism to antibiotics, research has been focused on immunotherapy. There are several bacterial cell components incorporated into subunit vaccines. Vaccine studies have often focussed on lipopolysaccharide (LPS) and the outer membrane proteins ...

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In silico determination and validation of oprL structure and b cell epitopes as vaccine candidate in Pseudomonas aeruginosa

In silico determination and validation of oprL structure and b cell epitopes as vaccine candidate in Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic, non-fermentative, gram-negative rod which is an important cause of nosocomial infection leading to septicemia and death. The mortality rate is higher than bacteremias caused by other gram-negative opportunistic pathogens. One of the most important features of the bacterium is its resistance to various antibacterial agents, and even newly developed antibiotics have failed to reduce the mortality rate associated with this organism. There is increasing ...

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In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

In silico potential vaccine against hps06257 in Haemophilus parasuis serovar 5

Haemophilus parasuis is a small, pleomorphic, NAD-dependent member of the family Pasteurellaceae. This bacterium is the etiological agent of Gl auml;sser rsquo;s disease in swine, which is characterized by polyserositis and arthritis. Once a sporadic disease, it has increased in prevalence and severity in recent years with the adoption of new production technologies which has led to pigs being susceptible to this infection. However, a lack of protective cross-immunity against some strains and ...

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Functional Exposed Amino Acids of LamB as a vaccine candidate for Vibriosis

Functional Exposed Amino Acids of LamB as a vaccine candidate for Vibriosis

Vibriosis is one of the most serious infectious diseases in fish and shellfish. However, due to thediversity of pathogens and their complicated serotypes, the progress in vaccine developmentagainst Vibriosis has been slow. LamB proteins (or maltoporins) are a family of OMPs. It formsa betabarrel composed of three monomers and ensures the transport of maltose and maltodextrinin Gram-negative bacteria reported that recombinant Aeromonas hydrophila outer membraneprotein 48, which belongs to the ...

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